Boosting salt resistance of short antimicrobial peptides.

نویسندگان

  • Hung-Lun Chu
  • Hui-Yuan Yu
  • Bak-Sau Yip
  • Ya-Han Chih
  • Chong-Wen Liang
  • Hsi-Tsung Cheng
  • Jya-Wei Cheng
چکیده

The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid β-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich peptide S1 were diminished at high salt concentrations, whereas the activities of its β-naphthylalanine end-tagged variants were less affected.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 8  شماره 

صفحات  -

تاریخ انتشار 2013